Name

IL5 Gene

interleukin 5

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

IL5RA Gene

interleukin 5 receptor, alpha

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

il5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL5 Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the IL5 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

IL5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL5 from the Pathway Commons Protein-Protein Interactions dataset.

il5ra Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5ra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5stimulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5stimulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5ralpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5ralpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5ra80 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5ra80 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5ra31197ag Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5ra31197ag in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5related Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5related in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il5il4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il5il4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL5RA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL5RA from the Pathway Commons Protein-Protein Interactions dataset.

IL5-mediated signaling events Gene Set

From PID Pathways

proteins participating in the IL5-mediated signaling events pathway from the PID Pathways dataset.