Name

IL6 Gene

interleukin 6

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]

IL6RP1 Gene

interleukin 6 receptor pseudogene 1

IL6ST Gene

interleukin 6 signal transducer

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

IL6R Gene

interleukin 6 receptor

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

IL6STP1 Gene

interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene 1

il6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL6 from the Pathway Commons Protein-Protein Interactions dataset.

IL6ST-PRKCD-STAT3 complex Gene Set

From CORUM Protein Complexes

proteins in the IL6ST-PRKCD-STAT3 complex protein complex from the CORUM Protein Complexes dataset.

Heterodimer complex (CDK9, IL6ST) Gene Set

From CORUM Protein Complexes

proteins in the Heterodimer complex (CDK9, IL6ST) protein complex from the CORUM Protein Complexes dataset.

plasma il6 levels Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasma il6 levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

il6 transcription Gene Set

From GAD Gene-Disease Associations

genes associated with the disease il6 transcription in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

il6tnfalpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6tnfalpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6vegf Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6vegf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6responsive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6responsive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6174 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6174 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stat3dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stat3dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6interleukin6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6interleukin6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6ralpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6ralpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6sil6rmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6sil6rmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6nfkappabstat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6nfkappabstat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6neutralizing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6neutralizing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6ra Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6ra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6treated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6treated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6creactive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6creactive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6related Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6related in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6inducible Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6inducible in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6634gicam1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6634gicam1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6ril6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6ril6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6activated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6activated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6tgfbetamediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6tgfbetamediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6643 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6643 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6sr Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6sr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6artgfbetammp9 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6artgfbetammp9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stgp130 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stgp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6il6r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6il6r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6rstat3mir34a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6rstat3mir34a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6jakstat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6jakstat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6cd44 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6cd44 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6receptorgp130coupled Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6receptorgp130coupled in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6st Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6st in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6sil6r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6sil6r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6gp130dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6gp130dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6raftstat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6raftstat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stimulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stimulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6rindependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6rindependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6explains Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6explains in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6jak2stat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6jak2stat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stat3tff3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stat3tff3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6synthesis Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6synthesis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6type Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6type in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6147gc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6147gc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6il6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6il6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6il8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6il8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6stat3hif1a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6stat3hif1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6174gg Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6174gg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6174gc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6174gc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6il10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6il10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il6tnfalphatlr4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il6tnfalphatlr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL6ST Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for IL6ST from the MSigDB Cancer Gene Co-expression Modules dataset.

IL6ST Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL6ST from the Pathway Commons Protein-Protein Interactions dataset.

IL6R Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL6R from the Pathway Commons Protein-Protein Interactions dataset.

IL6-mediated signaling events Gene Set

From PID Pathways

proteins participating in the IL6-mediated signaling events pathway from the PID Pathways dataset.