Name

ITGA8 Gene

integrin, alpha 8

Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

itga8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term itga8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ITGA8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ITGA8 from the Pathway Commons Protein-Protein Interactions dataset.

ITGA8-ITGB1 complex Gene Set

From CORUM Protein Complexes

proteins in the ITGA8-ITGB1 complex protein complex from the CORUM Protein Complexes dataset.