Name

ITPR2 Gene

inositol 1,4,5-trisphosphate receptor, type 2

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]

itpr2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term itpr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ITPR2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ITPR2 from the Pathway Commons Protein-Protein Interactions dataset.