Name

LATS1 Gene

large tumor suppressor kinase 1

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

lats1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lats1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LATS1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase LATS1 from the curated KEA Substrates of Kinases dataset.

LATS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LATS1 from the Pathway Commons Protein-Protein Interactions dataset.

LATS1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase LATS1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

LATS1-HTRA2-BIRC4 complex Gene Set

From CORUM Protein Complexes

proteins in the LATS1-HTRA2-BIRC4 complex protein complex from the CORUM Protein Complexes dataset.

lats12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lats12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lats1itch Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lats1itch in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Serine/threonine-protein kinase LATS1/ Warts Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine/threonine-protein kinase LATS1/ Warts protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL2210 (LATS1) Gene Set

From NURSA Protein Complexes

proteins in the BL2210 (LATS1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2212 (LATS1) Gene Set

From NURSA Protein Complexes

proteins in the BL2212 (LATS1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.