Name

LCK Gene

LCK proto-oncogene, Src family tyrosine kinase

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

lck Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lck in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LCK Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein LCK from the curated Hub Proteins Protein-Protein Interactions dataset.

LCK Gene Set

From KEA Substrates of Kinases

substrates of the kinase LCK from the curated KEA Substrates of Kinases dataset.

LCK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LCK from the Pathway Commons Protein-Protein Interactions dataset.

lck Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term lck in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

LCK Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase LCK from the curated PhosphoSitePlus Substrates of Kinases dataset.

lck and fyn tyrosine kinases in initiation of tcr activation Gene Set

From Biocarta Pathways

proteins participating in the lck and fyn tyrosine kinases in initiation of tcr activation pathway from the Biocarta Pathways dataset.

CD20-LCK-FYN-p75/80 complex Gene Set

From CORUM Protein Complexes

proteins in the CD20-LCK-FYN-p75/80 complex protein complex from the CORUM Protein Complexes dataset.

CD8A-LCK complex Gene Set

From CORUM Protein Complexes

proteins in the CD8A-LCK complex protein complex from the CORUM Protein Complexes dataset.

p56(LCK)-CAML complex Gene Set

From CORUM Protein Complexes

proteins in the p56(LCK)-CAML complex protein complex from the CORUM Protein Complexes dataset.

CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line) Gene Set

From CORUM Protein Complexes

proteins in the CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line) protein complex from the CORUM Protein Complexes dataset.

LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated Gene Set

From CORUM Protein Complexes

proteins in the LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated protein complex from the CORUM Protein Complexes dataset.

lckzap70cblb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lckzap70cblb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lckdeficient Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lckdeficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lckdependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lckdependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lckmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lckmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Lck-interacting transmembrane adapter 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lck-interacting transmembrane adapter 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.