LCT Gene


The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008]



This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

lct Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lct in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LCT Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LCT from the Pathway Commons Protein-Protein Interactions dataset.