Name

LEF1 Gene

lymphoid enhancer-binding factor 1

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

LEF1-AS1 Gene

LEF1 antisense RNA 1

lef1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lef1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LEF1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LEF1 from the Pathway Commons Protein-Protein Interactions dataset.

LEF1 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the LEF1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

LEF1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the LEF1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

Lef1-Tle1 complex Gene Set

From CORUM Protein Complexes

proteins in the Lef1-Tle1 complex protein complex from the CORUM Protein Complexes dataset.

Pax3-Lef1-Tle4 complex Gene Set

From CORUM Protein Complexes

proteins in the Pax3-Lef1-Tle4 complex protein complex from the CORUM Protein Complexes dataset.

Lef1-Tle1-Ctnnb1 complex Gene Set

From CORUM Protein Complexes

proteins in the Lef1-Tle1-Ctnnb1 complex protein complex from the CORUM Protein Complexes dataset.

lef1tcf Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lef1tcf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lef1tcf4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lef1tcf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LEF1, TCF1 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the LEF1, TCF1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

LEF1_UP.V1 Gene Set

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the LEF1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.