LIN28B Gene

lin-28 homolog B (C. elegans)

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

lin28b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lin28b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LIN28B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LIN28B from the Pathway Commons Protein-Protein Interactions dataset.