Name

LRP6 Gene

low density lipoprotein receptor-related protein 6

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

lrp6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lrp6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LRP6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LRP6 from the Pathway Commons Protein-Protein Interactions dataset.

wnt lrp6 signalling Gene Set

From Biocarta Pathways

proteins participating in the wnt lrp6 signalling pathway from the Biocarta Pathways dataset.

lrp65 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lrp65 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lrp6r611c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lrp6r611c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

lrp6icd Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lrp6icd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.