Name

LZTFL1 Gene

leucine zipper transcription factor-like 1

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]

lztfl1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lztfl1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

LZTFL1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for LZTFL1 from the Pathway Commons Protein-Protein Interactions dataset.