Name

MAP3K1 Gene

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

MAP3K10 Gene

mitogen-activated protein kinase kinase kinase 10

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

MAP3K13 Gene

mitogen-activated protein kinase kinase kinase 13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

MAP3K19 Gene

mitogen-activated protein kinase kinase kinase 19

MAP3K11 Gene

mitogen-activated protein kinase kinase kinase 11

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

MAP3K12 Gene

mitogen-activated protein kinase kinase kinase 12

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

MAP3K15 Gene

mitogen-activated protein kinase kinase kinase 15

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

MAP3K14-AS1 Gene

MAP3K14 antisense RNA 1

MAP3K14 Gene

mitogen-activated protein kinase kinase kinase 14

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

map3k1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP3K1 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein MAP3K1 from the curated Hub Proteins Protein-Protein Interactions dataset.

MAP3K1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K1 from the curated KEA Substrates of Kinases dataset.

MAP3K1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K1 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex Gene Set

From CORUM Protein Complexes

proteins in the CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex protein complex from the CORUM Protein Complexes dataset.

CHUK-IKBKB-MAP3K14 complex Gene Set

From CORUM Protein Complexes

proteins in the CHUK-IKBKB-MAP3K14 complex protein complex from the CORUM Protein Complexes dataset.

TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) Gene Set

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) protein complex from the CORUM Protein Complexes dataset.

Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) Gene Set

From CORUM Protein Complexes

proteins in the IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) protein complex from the CORUM Protein Complexes dataset.

B-raf-MAP3K11 complex Gene Set

From CORUM Protein Complexes

proteins in the B-raf-MAP3K11 complex protein complex from the CORUM Protein Complexes dataset.

Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

map3k10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

map3k14 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP3K1_knockout_245_GSE39240 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the MAP3K1_knockout_245_GSE39240 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

MAP3K14 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein MAP3K14 from the curated Hub Proteins Protein-Protein Interactions dataset.

MAP3K12-binding inhibitory protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MAP3K12-binding inhibitory protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

MAP3K10 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K10 from the curated KEA Substrates of Kinases dataset.

MAP3K11 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K11 from the curated KEA Substrates of Kinases dataset.

MAP3K12 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K12 from the curated KEA Substrates of Kinases dataset.

MAP3K13 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K13 from the curated KEA Substrates of Kinases dataset.

MAP3K14 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K14 from the curated KEA Substrates of Kinases dataset.

MAP3K14 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MAP3K14 from the MSigDB Cancer Gene Co-expression Modules dataset.

CBC12 (MAP3K1) Gene Set

From NURSA Protein Complexes

proteins in the CBC12 (MAP3K1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL7235 (MAP3K1) Gene Set

From NURSA Protein Complexes

proteins in the BL7235 (MAP3K1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

MAP3K10 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K10 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K12 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K13 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K13 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K14 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K14 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K15 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K15 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K11 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K11 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K10 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K10 from the curated PhosphoSitePlus Substrates of Kinases dataset.

MAP3K11 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K11 from the curated PhosphoSitePlus Substrates of Kinases dataset.

MAP3K12 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K12 from the curated PhosphoSitePlus Substrates of Kinases dataset.

MAP3K14 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K14 from the curated PhosphoSitePlus Substrates of Kinases dataset.