Name

MAP3K12 Gene

mitogen-activated protein kinase kinase kinase 12

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

MAP3K12 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K12 from the curated KEA Substrates of Kinases dataset.

MAP3K12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K12 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K12 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K12 from the curated PhosphoSitePlus Substrates of Kinases dataset.

MAP3K12-binding inhibitory protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MAP3K12-binding inhibitory protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.