MAP3K4 Gene

mitogen-activated protein kinase kinase kinase 4

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]

map3k4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP3K4 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K4 from the curated KEA Substrates of Kinases dataset.

MAP3K4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K4 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K4 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K4 from the curated PhosphoSitePlus Substrates of Kinases dataset.