Name

MATK Gene

megakaryocyte-associated tyrosine kinase

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

MATK Gene Set

From KEA Substrates of Kinases

substrates of the kinase MATK from the curated KEA Substrates of Kinases dataset.

MATK Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MATK from the MSigDB Cancer Gene Co-expression Modules dataset.

MATK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MATK from the Pathway Commons Protein-Protein Interactions dataset.

MATK Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MATK from the curated PhosphoSitePlus Substrates of Kinases dataset.