Harmonizome

minichromosome maintenance complex component 7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for MCM7 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM7 from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the MCM2-MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MCM2-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA replication licensing factor Mcm7 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the SC-9966 (MCM7) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL265 (MCM7) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.