Name

MED12 Gene

mediator complex subunit 12

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

MED12L Gene

mediator complex subunit 12-like

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]

med12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term med12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MED12 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for MED12 from the NURSA Protein-Protein Interactions dataset.

MED12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MED12 from the Pathway Commons Protein-Protein Interactions dataset.

med12but Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term med12but in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

med12mediator Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term med12mediator in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Mediator complex, subunit Med12, LCEWAV-domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mediator complex, subunit Med12, LCEWAV-domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Mediator complex, subunit Med12, catenin-binding Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mediator complex, subunit Med12, catenin-binding protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Mediator complex, subunit Med12 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mediator complex, subunit Med12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL2844 (MED12) Gene Set

From NURSA Protein Complexes

proteins in the BL2844 (MED12) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2841 (MED12) Gene Set

From NURSA Protein Complexes

proteins in the BL2841 (MED12) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2843 (MED12) Gene Set

From NURSA Protein Complexes

proteins in the BL2843 (MED12) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2842 (MED12) Gene Set

From NURSA Protein Complexes

proteins in the BL2842 (MED12) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

MED12L Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MED12L from the Pathway Commons Protein-Protein Interactions dataset.