MMP14 Gene

matrix metallopeptidase 14 (membrane-inserted)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

mmp14 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mmp14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MMP14 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MMP14 from the Pathway Commons Protein-Protein Interactions dataset.

ITGAV-ITGB8-MMP14-TGFB1 complex Gene Set

From CORUM Protein Complexes

proteins in the ITGAV-ITGB8-MMP14-TGFB1 complex protein complex from the CORUM Protein Complexes dataset.