Name

MSH3 Gene

mutS homolog 3

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

msh3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term msh3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MSH3 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MSH3 from the MSigDB Cancer Gene Co-expression Modules dataset.

MSH3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MSH3 from the Pathway Commons Protein-Protein Interactions dataset.

MSH2-MSH3 complex Gene Set

From CORUM Protein Complexes

proteins in the MSH2-MSH3 complex protein complex from the CORUM Protein Complexes dataset.

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Gene Set

From Reactome Pathways

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway from the Reactome Pathways dataset.