Harmonizome

MAX interactor 1, dimerization protein

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

From ENCODE Transcription Factor Targets

target genes of the MXI1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mxi1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MXI1 from the Pathway Commons Protein-Protein Interactions dataset.

From TRANSFAC Predicted Transcription Factor Targets

target genes of the MXI1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_SK-N-SH_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_MEL cell line_mm9_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_K562_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_HepG2_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_HeLa-S3_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_CH12.LX_mm9_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_H1-hESC_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MXI1_IMR-90_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mxi1leg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mxi10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.