Name

NLRP3 Gene

NLR family, pyrin domain containing 3

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

NLRP3P Gene

NLR family, pyrin domain containing 3 pseudogene

nlrp3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NLRP3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NLRP3 from the Pathway Commons Protein-Protein Interactions dataset.

nlrp3 inflammasome complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the nlrp3 inflammasome complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

nlrp3 inflammasome complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the nlrp3 inflammasome complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

nlrp3nlrp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3nlrp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nlrp3asc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3asc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nlrp3asccaspase1il1beta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3asccaspase1il1beta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nlrp3gene Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

nlrp3dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nlrp3dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

regulation of nlrp3 inflammasome complex assembly Gene Set

From GO Biological Process Annotations

genes participating in the regulation of nlrp3 inflammasome complex assembly biological process from the curated GO Biological Process Annotations dataset.

positive regulation of nlrp3 inflammasome complex assembly Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of nlrp3 inflammasome complex assembly biological process from the curated GO Biological Process Annotations dataset.

nlrp3 inflammasome complex assembly Gene Set

From GO Biological Process Annotations

genes participating in the nlrp3 inflammasome complex assembly biological process from the curated GO Biological Process Annotations dataset.

negative regulation of nlrp3 inflammasome complex assembly Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of nlrp3 inflammasome complex assembly biological process from the curated GO Biological Process Annotations dataset.

nlrp3 inflammasome complex Gene Set

From GO Cellular Component Annotations

proteins localized to the nlrp3 inflammasome complex cellular component from the curated GO Cellular Component Annotations dataset.

The NLRP3 inflammasome Gene Set

From Reactome Pathways

proteins participating in the The NLRP3 inflammasome pathway from the Reactome Pathways dataset.