NR0B2 Gene

nuclear receptor subfamily 0, group B, member 2

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

nr0b2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nr0b2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NR0B2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NR0B2 from the Pathway Commons Protein-Protein Interactions dataset.

SC-30169 (NR0B2) Gene Set

From NURSA Protein Complexes

proteins in the SC-30169 (NR0B2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.