Name

OGG1 Gene

8-oxoguanine DNA glycosylase

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

ogg1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ogg1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

OGG1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for OGG1 from the Pathway Commons Protein-Protein Interactions dataset.

ogg1326 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ogg1326 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ogg1xpc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ogg1xpc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ogg1ser326cys Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ogg1ser326cys in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.