OPRM1 Gene

opioid receptor, mu 1

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

oprm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term oprm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

OPRM1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for OPRM1 from the Pathway Commons Protein-Protein Interactions dataset.