P2RX7 Gene

purinergic receptor P2X, ligand gated ion channel, 7

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

p2rx7 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term p2rx7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

P2RX7 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for P2RX7 from the Pathway Commons Protein-Protein Interactions dataset.