Name

PARN Gene

poly(A)-specific ribonuclease

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

parn Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term parn in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PARN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PARN from the Pathway Commons Protein-Protein Interactions dataset.

mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Gene Set

From CORUM Protein Complexes

proteins in the mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) protein complex from the CORUM Protein Complexes dataset.