Harmonizome

PH domain and leucine rich repeat protein phosphatase 1

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PHLPP1 from the curated DEPOD Substrates of Phosphatases dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term phlpp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase PHLPP1 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PHLPP1 from the Pathway Commons Protein-Protein Interactions dataset.

From NURSA Protein Complexes

proteins in the BL2679 (PHLPP1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.