Name

PIAS3 Gene

protein inhibitor of activated STAT, 3

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

pias3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pias3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PIAS3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PIAS3 from the Pathway Commons Protein-Protein Interactions dataset.

PIAS3-SMAD3-P300 complex Gene Set

From CORUM Protein Complexes

proteins in the PIAS3-SMAD3-P300 complex protein complex from the CORUM Protein Complexes dataset.

E3 SUMO-protein ligase PIAS3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 SUMO-protein ligase PIAS3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.