Name

PITX2 Gene

paired-like homeodomain 2

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

pitx2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pitx2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PITX2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PITX2 from the Pathway Commons Protein-Protein Interactions dataset.

PITX2 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the PITX2 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

PITX2 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the PITX2 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

multi-step regulation of transcription by pitx2 Gene Set

From Biocarta Pathways

proteins participating in the multi-step regulation of transcription by pitx2 pathway from the Biocarta Pathways dataset.

pitx2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pitx2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

pitx2c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pitx2c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

pitx2interacting Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pitx2interacting in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.