PLA2G2A Gene

phospholipase A2, group IIA (platelets, synovial fluid)

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

pla2g2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pla2g2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PLA2G2A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PLA2G2A from the Pathway Commons Protein-Protein Interactions dataset.