Name

PLCG1-AS1 Gene

PLCG1 antisense RNA 1

PLCG1 Gene

phospholipase C, gamma 1

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

plcg1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term plcg1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PLCG1 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein PLCG1 from the curated Hub Proteins Protein-Protein Interactions dataset.

PLCG1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PLCG1 from the Pathway Commons Protein-Protein Interactions dataset.

PLCG1 events in ERBB2 signaling Gene Set

From Reactome Pathways

proteins participating in the PLCG1 events in ERBB2 signaling pathway from the Reactome Pathways dataset.