Name

PMEL Gene

premelanosome protein

This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

pmel Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pmel in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PMEL Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PMEL from the Pathway Commons Protein-Protein Interactions dataset.

pmel17 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pmel17 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

pmel17review Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pmel17review in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.