Name

POLG Gene

polymerase (DNA directed), gamma

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

POLG2 Gene

polymerase (DNA directed), gamma 2, accessory subunit

This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]

polg Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

POLG Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for POLG from the Pathway Commons Protein-Protein Interactions dataset.

polg1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polg1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

polg2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polg2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

polgammaa Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term polgammaa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

POLG2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for POLG2 from the Pathway Commons Protein-Protein Interactions dataset.