Harmonizome

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

From ENCODE Transcription Factor Targets

target genes of the PPARGC1A transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppargc1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PPARGC1A from the Pathway Commons Protein-Protein Interactions dataset.

From CORUM Protein Complexes

proteins in the Yy1-Ppargc1a complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Yy1-Ppargc1a-Frap1 complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the PPARGC1A_HepG2_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppargc1agly482ser in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PPARGC1A_NULL MUTATION_GDS2149_721_mouse_Brown adipocyte gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PPARGC1A_KO_GDS2391_299_mouse_brain striatum gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From NURSA Protein Complexes

proteins in the BL448 (PPARGC1A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL449 (PPARGC1A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways

proteins participating in the Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway from the Reactome Pathways dataset.