Name

PPM1D Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1D

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

PPM1D Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PPM1D from the curated DEPOD Substrates of Phosphatases dataset.

ppm1d Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppm1d in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PPM1D Gene Set

From KEA Substrates of Kinases

substrates of the kinase PPM1D from the curated KEA Substrates of Kinases dataset.

PPM1D Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for PPM1D from the MSigDB Cancer Gene Co-expression Modules dataset.

PPM1D Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PPM1D from the Pathway Commons Protein-Protein Interactions dataset.

ppm1dwip1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ppm1dwip1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL3066 (PPM1D) Gene Set

From NURSA Protein Complexes

proteins in the BL3066 (PPM1D) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.