Name

PRKACA Gene

protein kinase, cAMP-dependent, catalytic, alpha

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

PRKACA Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein PRKACA from the curated Hub Proteins Protein-Protein Interactions dataset.

PRKACA Gene Set

From KEA Substrates of Kinases

substrates of the kinase PRKACA from the curated KEA Substrates of Kinases dataset.

PRKACA Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for PRKACA from the MSigDB Cancer Gene Co-expression Modules dataset.

PRKACA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRKACA from the Pathway Commons Protein-Protein Interactions dataset.

PRKACA Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase PRKACA from the curated PhosphoSitePlus Substrates of Kinases dataset.

PRKACA_knockout_266_GSE20984 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the PRKACA_knockout_266_GSE20984 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.