PRKAR2A antisense RNA 1


protein kinase, cAMP-dependent, regulatory, type II, alpha

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) Gene Set

From CORUM Protein Complexes

proteins in the beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) protein complex from the CORUM Protein Complexes dataset.

prkar2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prkar2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL6392 (PRKAR2A) Gene Set

From NURSA Protein Complexes

proteins in the BL6392 (PRKAR2A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

PRKAR2A Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for PRKAR2A from the NURSA Protein-Protein Interactions dataset.

PRKAR2A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRKAR2A from the Pathway Commons Protein-Protein Interactions dataset.