Name

PSEN2 Gene

presenilin 2

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

psen2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term psen2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PSEN2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PSEN2 from the Pathway Commons Protein-Protein Interactions dataset.

APH1A-PSEN2-NCSTN complex Gene Set

From CORUM Protein Complexes

proteins in the APH1A-PSEN2-NCSTN complex protein complex from the CORUM Protein Complexes dataset.

Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) Gene Set

From CORUM Protein Complexes

proteins in the Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.

Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) Gene Set

From CORUM Protein Complexes

proteins in the Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.