PTBP1 Gene

polypyrimidine tract binding protein 1

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]


polypyrimidine tract binding protein 1 pseudogene

ptbp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ptbp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PTBP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTBP1 from the Pathway Commons Protein-Protein Interactions dataset.

DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) Gene Set

From CORUM Protein Complexes

proteins in the DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) protein complex from the CORUM Protein Complexes dataset.