prostaglandin I2 (prostacyclin) synthase

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

ptgis Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ptgis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PTGIS Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTGIS from the Pathway Commons Protein-Protein Interactions dataset.