Name

PYCARD Gene

PYD and CARD domain containing

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PYCARD-AS1 Gene

PYCARD antisense RNA 1

pycard Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pycard in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PYCARD Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PYCARD from the Pathway Commons Protein-Protein Interactions dataset.

pycardasc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pycardasc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.