Rap guanine nucleotide exchange factor (GEF) 2

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

rapgef2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rapgef2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RAPGEF2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RAPGEF2 from the Pathway Commons Protein-Protein Interactions dataset.

BL7869 (RAPGEF2) Gene Set

From NURSA Protein Complexes

proteins in the BL7869 (RAPGEF2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.