Name

RASGRP1 Gene

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

rasgrp1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rasgrp1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RASGRP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RASGRP1 from the Pathway Commons Protein-Protein Interactions dataset.

rasgrp1aptx Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rasgrp1aptx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.