Name

RNF213 Gene

ring finger protein 213

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

rnf213 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rnf213 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RNF213 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RNF213 from the Pathway Commons Protein-Protein Interactions dataset.