Name

RTKN Gene

rhotekin

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RTKN2 Gene

rhotekin 2

rtkn Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rtkn in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RTKN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RTKN from the Pathway Commons Protein-Protein Interactions dataset.

rtkn2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rtkn2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RTKN2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RTKN2 from the Pathway Commons Protein-Protein Interactions dataset.