Name

RUNX1 Gene

runt-related transcription factor 1

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RUNX1-IT1 Gene

RUNX1 intronic transcript 1

RUNX1T1 Gene

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

RUNX1 Gene Set

From CHEA Transcription Factor Targets

target genes of the RUNX1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

runx1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RUNX1 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the RUNX1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

RUNX1 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for RUNX1 from the MSigDB Cancer Gene Co-expression Modules dataset.

RUNX1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RUNX1 from the Pathway Commons Protein-Protein Interactions dataset.

RUNX1 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the RUNX1 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

RUNX1 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the RUNX1 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

RUNX1-17652178-JURKAT-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RUNX1-17652178-JURKAT-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

RUNX1-21571218-MEGAKARYOCYTES-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RUNX1-21571218-MEGAKARYOCYTES-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

RUNX1-20887958-HPC-7-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RUNX1-20887958-HPC-7-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

RUNX1-22412390-EML-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the RUNX1-22412390-EML-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

RUNX1-CBF-beta-DNA complex Gene Set

From CORUM Protein Complexes

proteins in the RUNX1-CBF-beta-DNA complex protein complex from the CORUM Protein Complexes dataset.

runx1mut Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1mut in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1usp42 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1usp42 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1prdm16 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1prdm16 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1etoinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1etoinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1evi1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1evi1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1mtg16 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1mtg16 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1t1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1t1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1mtg8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1mtg8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1cbfbeta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1cbfbeta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1runx1t1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1runx1t1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1aml1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1aml1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1recruited Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1recruited in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

runx1eto Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term runx1eto in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RUNX1_KO_GDS1511_251_mouse_Embryos at E12 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the RUNX1_KO_GDS1511_251_mouse_Embryos at E12 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

runx1_18671852_e8dot5_lof_mouse_gpl1261_gds1511 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the runx1_18671852_e8dot5_lof_mouse_gpl1261_gds1511 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

EPI-2593-1 (RUNX1) Gene Set

From NURSA Protein Complexes

proteins in the EPI-2593-1 (RUNX1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

RUNX1T1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RUNX1T1 from the Pathway Commons Protein-Protein Interactions dataset.

RUNX1-IT1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RUNX1-IT1 from the Pathway Commons Protein-Protein Interactions dataset.