Name

RYK Gene

receptor-like tyrosine kinase

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RYKP1 Gene

receptor-like tyrosine kinase pseudogene 1

ryk Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ryk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RYK Gene Set

From KEA Substrates of Kinases

substrates of the kinase RYK from the curated KEA Substrates of Kinases dataset.

RYK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RYK from the Pathway Commons Protein-Protein Interactions dataset.

Ryk-Dvl1 complex Gene Set

From CORUM Protein Complexes

proteins in the Ryk-Dvl1 complex protein complex from the CORUM Protein Complexes dataset.

Ryk-Wnt3a complex Gene Set

From CORUM Protein Complexes

proteins in the Ryk-Wnt3a complex protein complex from the CORUM Protein Complexes dataset.

Ryk-Wny1 complex Gene Set

From CORUM Protein Complexes

proteins in the Ryk-Wny1 complex protein complex from the CORUM Protein Complexes dataset.

Ryk-Wny1-Fzd8 complex Gene Set

From CORUM Protein Complexes

proteins in the Ryk-Wny1-Fzd8 complex protein complex from the CORUM Protein Complexes dataset.