Name

SALL3 Gene

spalt-like transcription factor 3

This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

sall3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sall3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SALL3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SALL3 from the Pathway Commons Protein-Protein Interactions dataset.