Name

SERPINC1 Gene

serpin peptidase inhibitor, clade C (antithrombin), member 1

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

serpinc1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term serpinc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SERPINC1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for SERPINC1 from the NURSA Protein-Protein Interactions dataset.

SERPINC1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SERPINC1 from the Pathway Commons Protein-Protein Interactions dataset.