Name

SERPINE1 Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

serpine1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term serpine1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SERPINE1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SERPINE1 from the Pathway Commons Protein-Protein Interactions dataset.

serpine1fosb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term serpine1fosb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.